BC Environmental and Occupational Health Research Network

The project will screen a limited number of disinfection by-products (DBPs) for endocrine activity using assays developed under the Environmental Protection Agency’s (EPA’s) Endocrine Disruptor Screening Program (EDSP). The primary objective will be to screen regulated DBPs, including individual trihalomethane (THM) and haloacetic acid (HAA) species; a few typical DBP mixtures; and a few emerging DBPs based upon their structure, genotoxicity, and/or occurrence. In order to ensure the integrity of the results, the project will first develop a quality assurance and control plan that includes experimental controls and demonstrate the assays using proven endocrine disruptors.