BC Environmental and Occupational Health Research Network

The IMVC program will support research using appropriate human and animal studies to address basic immunological questions leading to the discovery of novel immune-based mechanisms relevant to the prevention or control of human virus infection. Successful applicants will justify their choices of experimental systems and approaches in the context of their ultimate physiological relevance to human disease. Proposed research must be focused on the analysis and characterization of host immune mechanisms to address basic scientific questions on the immunology of anti-virus responses, generated either to infection or vaccination. Immune recognition of infected cells, anti-virus defenses, and mechanisms of virus clearance in different tissues are among the major research areas in need of further study; several specific areas of interest and examples are briefly described below. These and other research areas may be addressed in response to this FOA in the context of defining new immune mechanisms relevant to viral disease in humans.