BC Environmental and Occupational Health Research Network

This request seeks carefully designed, hypothesis-driven studies that will determine mechanisms of persistent cellular re-programming observed in the diabetic state. Phenotypic changes observed in the persistent diabetic state include various metabolic perturbations, inflammation, and fibrosis. Priority will be given to proposals that aim to find a causal link between disease-specific cellular changes (including but not limited to chromatin biology / epigenetic factors) and the pathogenesis of type 1 diabetic complications.