BC Environmental and Occupational Health Research Network

The National Heart, Lung, and Blood Institute (NHLBI) solicits grant applications under this Funding Opportunity Announcement (FOA) that are aimed at Phase I translation (T1) of recent advances in understanding the molecular basis of endogenous, self-sustaining daily cycles (circadian) in cellular function and gene expression to improve our understanding of heart, lung, and blood disease pathogenesis. This FOA aims to stimulate the application of recent discoveries and advances in understanding how circadian periodicity regulates the cells and metabolism of non-neural peripheral tissues to models of disease and avenues for the investigation of heart, lung, and blood disease risk, pathogenesis, diagnosis, treatment, and prevention. The scope of this FOA includes the impact of peripheral tissue circadian misalignment or disruption on metabolic, inflammatory, and thrombotic disease pathways. For the purpose of this FOA, the main thrust of research on circadian misalignment should be on elucidating molecular mediators and not potential environmental sources of exposure such as “jet lag.” Studies may also address how other genes are implicated in clock regulation.