BC Environmental and Occupational Health Research Network

This project seeks to evaluate currently regulated drinking water contaminants considering the thyroidal endpoint used to develop the US Environmental Protection Agency’s reference dose (RfD) for perchlorate as well RfDs based on other endocrine-related endpoints. Specifically, the literature review will compare other thyroid agonists such as nitrate, nitrite, chlorate, and bromate to the criteria used to establish the perchlorate RfD. In addition, consideration will be given to other endocrine related endpoints such as the impacts of atrazine on the luteinizing hormone (LH) surge. The product of this activity will be a white paper that hypothesizes how regulations for other drinking water contaminants might change if the criteria for developing the perchlorate or atrazine RfDs were applied to them.